He knew they would face enemies. So, whenever the Ark set out, Moses would shout, “Arise O Lord, and let your enemies be scattered! Let them flee before you (Numbers 10:35)!”
We know we face enemies too. Though unseen, they are evil spirits with mighty power. We, like Moses, can ask God to chase them away.
Humble yourselves before God. Resist the devil, and he will flee from you (James 4:7).